Bizarre Foods focuses on regional cuisine from around the world which is typically perceived by Americans as being gross, unique, or, of course, bizarre. In each episode, Zimmern focuses on the cuisine of a particular country or region. He typically shows how the food is procured, where it is served, and, usually without hesitation, eats it.

Originally a one-hour documentary titled Bizarre Foods of Asia, repeated showings on the Travel Channel drew consistent, considerable audiences. In late 2006, it was decided to turn the documentary into a weekly, one-hour show with the same premise and with Andrew Zimmern as the host. In 2009, Zimmern took a break from Bizarre Foods to work on a season of the spin-off Bizarre World which will not be airing anymore.

Zimmern ends every episode with his line "If it looks good, eat it. If it doesn't look good, eat it anyway."

Frog sashimi (plus the frog's beating heart), lizard sake, fugu, turtle, Kobe beef, bird's nest soup, frog ovary soup, spirulina, bat, Belacan, durian.

Andrew participates in a cleansing ritual.

Andrew goes on a sled dog tour.

Tongue sandwich, geoduck, live lobster, ceviche, pupusas, worm pretzels, maggot pupae, tarantula pops, teriyaki cockroaches, jellyfish salad, sea cucumber salad, goose intestine, frog congee, salo.

Andrew also visits a fish sauce factory.

Andrew visits the Sahakari Spice Farm and tries Ayurveda and yoga.

Andrew visited the Rungis market, a mustard shop, Paris's best cheese shop, and a snail farm.